Stem cell divisions and cancer
نویسندگان
چکیده
منابع مشابه
Symmetric vs. Asymmetric Stem Cell Divisions: An Adaptation against Cancer?
Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis. It is well understood that the two types of cell divisions differ in terms of the stem cells' flexibility to expand wh...
متن کاملOn the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk
We are pleased that the analyses on smoking and radiation performed by Little et al. support the idea that the effects of various environmental factors on cancer risk do not correlate significantly with the lifetime number of stem cell divisions. This provides further evidence that the correlation we obtained for the U.S., and similarly found across the rest of the world, is in general not due ...
متن کاملConcise Review: Asymmetric Cell Divisions in Stem Cell Biology
Somatic stem cells are rare cells with unique properties residing in many organs and tissues. They are undifferentiated cells responsible for tissue regeneration and homeostasis, and contain both the capacity to self-renew in order to maintain their stem cell potential and to differentiate towards tissue-specific, specialized cells. However, the knowledge about the mechanisms controlling somati...
متن کاملOverexpression of cancer stem cell marker Lgr5 in colorectal cancer patients and association with pathologic findings
Background: To determine the expression of cancer stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) in colorectal carcinoma samples compared to normal adjacent tissue and any possible association with clinicopathological findings. Methods: This study was performed on forty samples of cancerous colorectal tissues (case group) and their adjacent normal mucosa (c...
متن کاملThe Role of Symmetric Stem Cell Divisions in Tissue Homeostasis
Successful maintenance of cellular lineages critically depends on the fate decision dynamics of stem cells (SCs) upon division. There are three possible strategies with respect to SC fate decision symmetry: (a) asymmetric mode, when each and every SC division produces one SC and one non-SC progeny; (b) symmetric mode, when 50% of all divisions produce two SCs and another 50%-two non-SC progeny;...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2015
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2015.166